Learn about Hepatitis B Antigen & Antibody medical tests, including what the tests are used for, why a doctor may order a test, how a test will feel, and what the results may mean.
Hepatitis B is an infection of the liver caused by the hepatitis B virus (HBV). Hepatitis B blood tests detect viral proteins (antigens), the antibodies that are produced in response to an infection, or detect or evaluate the genetic material (DNA) of the virus. The pattern of test results can identify a person who has a current active infection, was exposed to HBV in the past, or has immunity as a result of vaccination.
To determine whether acute signs and symptoms, such as jaundice, fever and fatigue, are due to hepatitis B infection; two tests, hepatitis B surface Ag and hepatitis B core antibody IgM, may be performed as part of an acute viral hepatitis panel along with tests for hepatitis A (HAV) and hepatitis C (HCV) to determine which virus may be causing the infection.
A blood sample drawn from a vein in your arm. You may want to wear a shirt with sleeves that can easily be rolled up to make it easier to collect the blood sample. This usually takes less than five minutes.
The tests for hepatitis B may be ordered individually but are often ordered in some combination, depending on the reason for testing. Results of the tests are typically evaluated together. Sometimes the meaning of one result depends on the result of another test. However, not all tests are performed for all people.
Interpretation | HBsAg | HBsAb (anti-HBs) | HBcAb (Anti-HBc) |
---|---|---|---|
Not Immune - Get Vaccinated Has not been infected, but still at risk for possible hepatitis B infection. Get the vaccine. |
- | - | - |
Immune – Protected Surface antibodies present due to natural infection. Has recovered from a prior hepatitis B infection. Cannot infect others. |
- | + | + |
Immune – Protected Has been vaccinated. Does not have the virus. No vaccine is needed. |
- | + | - |
Infected - Need More Testing Positive surface antigen (HBsAg), which means hepatitis B virus is present. Can spread the virus to others. Find a doctor who knows about hepatitis B for more tests and care. |
+ | - | + |
Could be Infected - Need More Testing Different interpretations are possible. Person might be infected, susceptible, or have a resolved infection. |
- | - | + |